TGFB1I1 Antibodies

Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Functions as a molecular adapter coordinating multiple protein-protein interactions in the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membranes and regulates the Wnt and TGFB signaling pathways.

May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity.

Gene Information

Human
Gene Name:	TGFB1I1
Uniprot:	O43294
Entrez:	7041

Family

Belongs to:
paxillin family

Alternative Names

Androgen receptor coactivator 55 kDa protein; androgen receptor coactivator ARA55; Androgen receptor-associated protein of 55 kDa; ARA55; ARA55Hydrogen peroxide-inducible clone 5 protein; HIC5; HIC-5; TGFB1I1; transforming growth factor beta 1 induced transcript 1; transforming growth factor beta-1-induced transcript 1 protein; TSC-5

Molecular Weight

Mass (kDA):
49.814 kDA

Genomic Context

Human
Location:	16p11.2
Sequence:	16; NC_000016.10 (31472152..31477960)

Tissue Specificity

Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).

Subcellular Localizations

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Associated with the actin cytoskeleton; colocalizes with stress fibers.

Diseases

• Tissue Adhesions
• Malignant Neoplasms
• Malignant Neoplasm Of Prostate
• Prostatic Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Carcinoma
• Neoplasm Metastasis
• Hypertrophy
• Cell Invasion
• Neoplasms, Hormone-dependent
• Mammary Neoplasms

• Atrophy
• Cicatrix
• Malignant Neoplasm Of Breast
• Infertility
• Cytomegalovirus Infections
• Pain

Interacting Proteins

• ITGA4
• PTK2
• TRAF4

Pathways

• Localization
• Cell Migration
• Senescence
• Cell Growth
• Nuclear Export
• Cell Adhesion
• Cellular Senescence
• Cell Motility
• Receptor Transactivation
• Cell Differentiation
• Cell Proliferation
• Endothelial Cell Migration
• Cell Death

• Platelet Activation
• Regulation Of Growth
• Aging
• Platelet Aggregation
• Translation
• Blood Vessel Development
• Rna Interference

PTMs

• Phosphorylation

• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TGFB1I1

Best Uses Of The TGFB1I1 Marker

The TGFB1I1Marker is a versatile peptide, with many uses. TGFB1I1 can be used to study a variety of biological systems. For research projects that require special samples or applications, Boster scientists may submit their results. Scientists can be awarded product credits for their work. This marker is universally applicable to scientists worldwide.

TGFB1I1 a multifunctional peptide

TGFB1 is a multifunctional peptide with high conservation that could be used as a therapeutic candidate to treat Alzheimer's disease (AD). Although it is not yet known what its role is in the pathogenesis AD, several diseases have been linked to it. A 1999 study suggested that TGFB1 may be linked to various types of cancers and bone diseases.

TGFB1 increases the permeability of alveolar epithelial cells in vitro, probably due to its role in the depletion of intracellular glutathione. Pittet et al. Pittet et.al. concluded TGFB was crucial in pulmonary edema following acute lungs injury. As such, blocking TGFB from the lungs could be a therapeutic strategy.

In a study of patients with CED, a team of Japanese researchers identified three mutations in the TGFB1 gene. These mutations may cause an excessive production of TGF beta, possibly by hyperactivation. They can also cause premature degradation of the protein, possibly through hyperactivation. It is unknown whether these mutations increase TGFbeta's levels in the bone.

TGFB1I1 was also found to be a key player in apoptosis. This peptide is responsible for the production of multiple growth factor in blood and skin. It may also play a role in the development of DiGeorge syndrome. The study suggests the TGFB1 pathway may also play a part in DiGeorge syndrome.

The researchers concluded that DMD requires TGFB1 to initiate muscle fibrosis. Gene therapy may improve the outcome for DMD. Patients with DMD could benefit greatly from the discovery a new drug that targets this protein. But there are still challenges. TGFB1I1 could be a promising candidate for further research.

Primary antibodies of high-affinity

Antibody can refer either to whole antibodies or antigen-binding fractions. Glycoproteins are composed of two heavy chains, one light chain with disulfide links and a variable or constant area. Each heavy chain is composed of three domains: the variable-, constant-, and antigenspecific' regions. Monoclonal antibodies bind the TGFB1I1 marker.

ELISA Kits

Boster Bio TGFFB1I1 is a protein with two forms. It is produced in a mature form and a late form. The mature form is also known as beta1-LAP, and the latent form is associated with a binding protein called latent TGF-beta1-binding protein (LTGF-b1). The standard TGFbeta1 ELISA kit uses recombinant TGFbeta1 with a molecular mass of 100 KDa.

Boster Bio Anti-HIC5/TGFB1I1 Antibody (catalog number A04630-1) can be used to perform ELISAs that are more sensitive. These antibodies were validated against over 250 tissues. The antibodies are also validated quantitatively using a panel recombinant and untransfected cell lines.

GM-CSF

The TGFB1I1 molecule, a polypeptide, is composed of the amino acid sequence of a naturally-occurring molecule. This molecule is preferably from the murine or human GM-CSF superfamily. This fusion polypeptide is the perfect choice for detecting TGFb1 and other proteins in a variety of biological samples.

IL-17

The TGFB1I1 mark is a transcription element that regulates the production of a range of molecules with direct antibiotic activity. These molecules include b–defensins (mucins), calgranulins and calgranulins. Human b-defensin 2 binds to CCR6 and mediates the recruitment of DCs.

IL-17A is a related cytokine that has a high potential for synergy. The TGFB1I1 marker allows researchers to distinguish between the two isoforms. Both are involved the inflammation of skin and may be problematic in psoriasis. As a result, targeting IL-17 signaling molecules may improve clinical treatments.

The TGFB1I1 genes is located in a region that expresses IL-17R. IL-17R subunits are single transmembrane proteins that have two fibronectin III-like domains (FN domains). This protein is used in IL-17F to regulate Th27 cells' activity. It also acts to dock TRAF proteins.

Multiple functions play in the immune system's TGFB1I1 genetic. It plays an important role in controlling host development and immune responses to nematode infections. It inhibits the production siderophores of the catecholate type, which are essential for bacterial survival. IL-17 is also an important regulator of the gene 24p3.

There are two types Th27-cell types: natural Th27 and adaptive Th27. Natural Th27 cells are capable of producing the chemokines CR6 and CCR4, while adaptive Th27 cells can produce TGFb. In mice, these cells are a major source of IL-17A. IL-17 plays a significant role in regulating immune reactions in a number different tissues. Th27 cells are also responsible in producing antibodies and anti-inflammatory cytokines including IL-17.