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- Table of Contents
Facts about Methylcytosine dioxygenase TET1.
Conversion of 5mC to 5hmC, 5fC and 5caC probably constitutes the initial step in cytosine demethylation. Methylation in the C5 position of cytosine bases is an epigenetic modification of the mammalian genome that has a significant role in transcriptional regulation.
Mouse | |
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Gene Name: | Tet1 |
Uniprot: | Q3URK3 |
Entrez: | 52463 |
Belongs to: |
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TET family |
bA119F7.1; CXXC finger 6; CXXC6; CXXC6FLJ10839; FLJ41442; KIAA1676CXXC-type zinc finger protein 6; LCX; LCXEC 1.14.11.n2; Leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1; Ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1
Mass (kDA):
219.261 kDA
Mouse | |
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Location: | 10 B4|10 32.48 cM |
Sequence: | 10; |
Present in embryonic stem cells (ES cells).
PMID: 20639862 by Ito S., et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.
PMID: 21496894 by Guo J.U., et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.