Protein TESPA1 (TESPA1)

Required for the growth and maturation of T-cells, its role being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes.

May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake through the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. .