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PLEKHM1 Antibodies
AND PLEKHM1 ELISA kits, PLEKHM1 Proteins
Many biological assays use antibodies to detect PLEKHM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLEKHM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLEKHM1 antibodies...
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PLEKHM1 Overview
Facts about Pleckstrin homology domain-containing family M member 1.
Pleckstrin homology domain-containing family M member 1 (PLEKHM1)
Proposed to function as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145).
Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950).
Gene Information
| Human | |
|---|---|
| Gene Name: | PLEKHM1 |
| Uniprot: | Q9Y4G2 |
| Entrez: | 9842 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
162 kDa adapter protein; AP162; hsa-mir-4315-1; KIAA0356; microRNA 4315-1; PH domain-containing family M member 1
Molecular Weight
Mass (kDA):
117.443 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (45434262..45490775, complement) |
Tissue Specificity
Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predominantly expressed in the breast carcinoma cell line MCF-7.
Subcellular Localizations
Cytoplasm. Endosome membrane. Lysosome. Lysosome membrane. Localizes to the external membrane of autolysosomes (PubMed:25498145). In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV) (PubMed:25500191).
Diseases
- Albers-schonberg Disease
- Osteosclerosis
- Malignant Neoplasms
- Sclerosis
- Malnutrition
- Lipogranuloma
- Malignant Tumor Of Colon
- Pancytopenia
- Malignant Neoplasm Of Lung
- Carcinoma
- Carcinogenesis
- Dandy-walker Syndrome
Pathways
- Bone Resorption
- Transport
- Osteoclast Differentiation
- Secretion
- Cell Cycle
- Bone Remodeling
- Protein Secretion
- Prenylation
- Exocytosis
PTMs
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLEKHM1
bosterbio.com/bosterbio-gene-info-cards/PLEKHM1
References
PMID: 12820725 by Hartel-Schenk S., et al. Novel adapter protein AP162 connects a sialyl-Le(x)-positive mucin with an apoptotic signal transduction pathway.
PMID: 17404618 by van Wesenbeeck L., et al. Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans.