Telomeric repeat-binding factor 2 (TERF2)

Binds the telomeric double-stranded 5'-TTAGGG-3' replicate and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, for example, shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo.

Part of the shelterin complex (telosome) that is involved in the regulation of telomere length and security. Shelterin partners with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; with no protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.