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- Table of Contents
Facts about Telomeric repeat-binding factor 1.
Part of the shelterin complicated (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; with no protective activity, telomeres are no longer concealed from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Human | |
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Gene Name: | TERF1 |
Uniprot: | P54274 |
Entrez: | 7013 |
Belongs to: |
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No superfamily |
NIMA-interacting protein 2; PIN-2; PIN2hTRF1-AS; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; telomeric repeat-binding factor 1; TERF1; TRBF1; TRF1; TRF-1; TRF1FLJ41416; TRFt-TRF1; TTAGGG repeat-binding factor 1
Mass (kDA):
50.246 kDA
Human | |
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Location: | 8q21.11 |
Sequence: | 8; NC_000008.11 (73008856..73048123) |
Highly expressed and ubiquitous. Isoform Pin2 predominates.
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
PMID: 7502076 by Chong L., et al. A human telomeric protein.
PMID: 9326950 by Broccoli D., et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.