Very-long-chain enoyl-CoA reductase (TECR)

Catalyzes the final of the four responses of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic procedure, allows the addition of 2 carbons to the chain of long- and quite long-chain fatty acids/VLCFAs each cycle.

This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate into an acyl-CoA which may be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different string lengths which are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.