Transcriptional enhancer factor TEF-5 (TEAD3)

Transcription factor which plays an integral role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its own regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its own regulatory protein MOB1, which then phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.