Tudor domain-containing protein 3 (TDRD3)

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails correlated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins in these arginine- methylated loci.

In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. .