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TDP2 Antibodies
AND TDP2 ELISA kits, TDP2 Proteins
Many biological assays use antibodies to detect TDP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TDP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TDP2 antibodies...
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TDP2 Infographic by Boster Bio
All TDP2 Products
Product
Figures
Specificity
Applications
Price
Human
WB
$523
Cat # M01804
100 µl
Cat # M01804
100 µl
TDP2 Overview
Facts about Tyrosyl-DNA phosphodiesterase 2.
Tyrosyl-DNA phosphodiesterase 2 (TDP2)
DNA repair enzyme that can remove a variety of covalent adducts from DNA via hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue.
The 5'-tyrosyl DNA phosphodiesterase action can allow the fix of TOP2-induced DNA double-strand breaks/DSBs with no need for nuclease activity, creating a'clean' DSB with 5'-phosphate termini which are prepared for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive action of TOP2.
Gene Information
| Human | |
|---|---|
| Gene Name: | TDP2 |
| Uniprot: | O95551 |
| Entrez: | 51567 |
Family
| Belongs to: |
|---|
| CCR4/nocturin family |
Alternative Names
AD022; dJ30M3.3; EAP2; EAPII; EC 3.1.4.-; ETS1-associated protein 2; ETS1-associated protein II; MGC111021,5'-Tyr-DNA phosphodiesterase; MGC9099,5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associated protein; TTRAPTRAF and TNF receptor-associated protein; Tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2
Molecular Weight
Mass (kDA):
40.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p22.3 |
| Sequence: | 6; NC_000006.12 (24649979..24666899, complement) |
Tissue Specificity
Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003).
Subcellular Localizations
Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.; Cytoplasm. (Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation.
Diseases
- Malignant Neoplasms
- Dyslexia
- Neoplasms
- Instabilities, Chromosomal
- Neoplasm Metastasis
- Neurodegenerative Disorders
- Malignant Neoplasm Of Lung
- Parkinson Disease
- Tumor Angiogenesis
- Acute Promyelocytic Leukemia
- Neuroblastoma
- Cell Transformation, Neoplastic
- Lung Neoplasms
Pathways
- Angiogenesis
- Cell Development
- Dna Repair
- Proteolysis
- Localization
- Inflammatory Response
- Dna Ligation
- Ribosome Biogenesis
- Reverse Transcription
- Cell Cycle
PTMs
- Cleavage
Research Areas
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TDP2
bosterbio.com/bosterbio-gene-info-cards/TDP2
References
PMID: 10764746 by Pype S., et al. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
PMID: 12743594 by Pei H., et al. EAPII interacts with ETS1 and modulates its transcriptional function.