TCP11 Antibodies

AND TCP11 ELISA kits, TCP11 Proteins

Many biological assays use antibodies to detect TCP11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCP11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCP11 antibodies...

We validate the specificity of these antibodies to TCP11 by testing them on tissues known to express TCP11 positively and negatively. Browse below to find the TCP11 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: TCTA

TCP11 Infographic by Boster Bio

All TCP11 Products

Product

Figures

Specificity

Applications

Price

TCP11 (NM_001093728) Human Recombinant Protein

$1249
Cat # PROTQ8WWU5
20 µg

TCP11 (NM_001093728) Human Over-expression Lysate

Human

$960
Cat # LS006954
100 µg

TCP11 Overview

Facts about T-complex protein 11 homolog.

TCP11 3D structure. Source: alphafold

T-complex protein 11 homolog (TCP11)

Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) in the sperm membrane that may regulate the activity of the adenylyl cyclase cAMP pathway.

Gene Information

Human
Gene Name:	TCP11
Uniprot:	Q8WWU5
Entrez:	6954

Family

Belongs to:

TCP11 family

Alternative Names

D6S230E; KIAA0229; MGC111103; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (mouse); T-complex protein 11 homolog

Molecular Weight

Mass (kDA):
56.141 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (35118064..35141410, complement)

Tissue Specificity

Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) (PubMed:21597245). Testis-specific (PubMed:11756566). Isoform 1, isoform 2 and isoform 3 are expressed in sperm (PubMed:21597245).

Subcellular Localizations

Membrane; Single-pass membrane protein. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.

Diseases

Ulcerative Colitis
Ulcer
Inflammatory Bowel Diseases
Infertility
Sterility
Intestinal Diseases

Colitis

Pathways

Fertilization
Acrosome Reaction
Spermatogenesis
Pollen Development
Metaphase
Interphase

Localization

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCP11

References

PMID: 11756566 by Ma Y., et al. Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.

PMID: 12545228 by Ma Y.X., et al. Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene.