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TCL1A Antibodies
AND TCL1A ELISA kits, TCL1A Proteins
Many biological assays use antibodies to detect TCL1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCL1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCL1A antibodies...
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TCL1A Overview
Facts about T-cell leukemia/lymphoma protein 1A.
T-cell leukemia/lymphoma protein 1A (TCL1A)
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3.
Promotes nuclear translocation of AKT1.Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. .
Gene Information
| Human | |
|---|---|
| Gene Name: | TCL1A |
| Uniprot: | P56279 |
| Entrez: | 8115 |
Family
| Belongs to: |
|---|
| TCL1 family |
Alternative Names
Oncogene TCL1; Oncogene TCL-1; Protein p14 TCL1; T-cell leukemia/lymphoma 1A; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1A; TCL1-PEN; TCL1T-cell leukemia/lymphoma protein 1A
Molecular Weight
Mass (kDA):
13.46 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.13 |
| Sequence: | 14; NC_000014.9 (95694160..95714155, complement) |
Tissue Specificity
Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Subcellular Localizations
Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.
Diseases
- Leukemia
- Lymphoma
- Neoplasms
- Leukemia, T-cell
- Malignant Neoplasms
- Chronic Lymphocytic Leukemia
- Lymphoid Leukemia
- Prolymphocytic Leukemia
- Chromosomal Translocation
- B-cell Lymphomas
- T-cell Prolymphocytic Leukemia
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
Interacting Proteins
- AKT1
- ALS2CR12
- CALCOCO2
- CARD9
- CEP55
- DNMT3A
- EP300
- FOS
- GOLGA2
- JUN
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Differentiation
- Localization
- Methylation
- Cell Growth
- Transport
- Immune Response
- Tropism
- Cell Cycle
- Cell Development
- B Cell Differentiation
- Gene Silencing
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCL1A
bosterbio.com/bosterbio-gene-info-cards/TCL1A
References
PMID: 7809072 by Virgilio L., et al. Identification of the TCL1 gene involved in T-cell malignancies.
PMID: 7987816 by Fu T.-B., et al. Characterization and localization of the TCL-1 oncogene product.