Transcription factor 7 Antibodies

AND TCF7 ELISA kits, Transcription factor 7 Proteins

Many biological assays use antibodies to detect Transcription factor 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor 7 antibodies...

We validate the specificity of these antibodies to Transcription factor 7 by testing them on tissues known to express TCF7 positively and negatively. Browse below to find the TCF7 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCF7 Infographic by Boster Bio

All TCF7 Products

Product

Figures

Specificity

Applications

Price

Anti-TCF-1 TCF7 Antibody

Human, Mouse

$399
Cat # A01315
100μl

Anti-TCF7 Antibody Picoband™

1 Citations 4 Q&As

Human, Mouse

$370
Cat # A01315-2
100 μg/vial

Anti-TCF-1 (F26) TCF7 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A01315-1
100ul

TCF7 (NM_201634) Human Over-expression Lysate

Human

$628
Cat # LS006932
100 µg

TCF7 Overview

Facts about Transcription factor 7.

TCF7 3D structure. Source: alphafold

Transcription factor 7 (TCF7)

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes.

Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene.

Gene Information

Human
Gene Name:	TCF7
Uniprot:	P36402
Entrez:	6932

Family

Belongs to:

TCF/LEF family

Alternative Names

FLJ36364; MGC47735; T-cell factor 1; T-cell specific; TCF1; TCF7; TCF-7; transcription factor 7 (T-cell specific, HMG-box)

Molecular Weight

Mass (kDA):
41.642 kDA

Genomic Context


Human

Location:	5q31.1
Sequence:	5; NC_000005.10 (134114681..134148229)

Tissue Specificity

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Malignant Tumor Of Colon
Diabetes Mellitus
Autoimmunity
Diabetes Mellitus, Insulin-dependent
Colonic Neoplasms
Lymphoma
Malignant Paraganglionic Neoplasm
Colorectal Cancer
Tissue Adhesions

Malignant Neoplasm Of Breast
Colorectal Neoplasms
Leukemia
Hypoxia
Dysequilibrium Syndrome
Crest Syndrome
Adenoma

Interacting Proteins

CTNNB1
MLLT11

Pathways

Cell Development
Cell Differentiation
T Cell Differentiation
Localization
Cell Proliferation
Pathogenesis
Cell Cycle
Osteoblast Differentiation
Cell Growth
Cell Maturation
Cell Adhesion
Cell Activation
T Cell Activation

Cell-cell Adhesion
Dna Methylation
Regeneration
Tissue Homeostasis
Regulation Of Gene Expression
Methylation
Neural Tube Closure

PTMs

Phosphorylation
Methylation

Demethylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCF7

References

PMID: 1989880 by van de Wetering M., et al. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

PMID: 1569101 by van de Wetering M., et al. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

1 Publications of Boster Transcription factor 7 Antibodies & ELISA Kits

PubMed ID: 10.1038/s41420-021-00775-8, LncRNA4930473A02Rik promotes cardiac hypertrophy by regulating TCF7 via sponging...

*More publications can be found for each product on its corresponding product page