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TBL1X Antibodies
AND TBL1X ELISA kits, TBL1X Proteins
Many biological assays use antibodies to detect TBL1X, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBL1X in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBL1X antibodies...
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TBL1X Infographic by Boster Bio
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TBL1X Overview
Facts about F-box-like/WD repeat-containing protein TBL1X.
F-box-like/WD repeat-containing protein TBL1X (TBL1X)
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to atomic receptor-regulated transcription units (PubMed:14980219). Plays an important role in transcription activation mediated by nuclear receptors.
Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). .
Gene Information
| Human | |
|---|---|
| Gene Name: | TBL1X |
| Uniprot: | O60907 |
| Entrez: | 6907 |
Family
| Belongs to: |
|---|
| WD repeat EBI family |
Alternative Names
EBI; SMAP55; TBL1transducin (beta)-like 1; transducin (beta)-like 1X-linked; X-linked
Molecular Weight
Mass (kDA):
62.496 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp22.31-p22.2 |
| Sequence: | X; NC_000023.11 (9463295..9719740) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Colocalized with MECP2 to the heterochromatin foci.
Diseases
- Complete Hearing Loss
- Sensorineural Hearing Loss (disorder)
- Coronary Heart Disease
- Malignant Neoplasms
- Mammary Neoplasms
- Heart Diseases
- Albinism, Ocular
- Albinism
- Aortic Coarctation
- Stenosis
- Tumor Progression
Interacting Proteins
- GPS2
- TINF2
Pathways
- Cytokinesis
- Cell Division
- Cell Migration
- Response To Stress
- Mitosis
- Localization
- Chromosome Segregation
- Regulation Of Cytokinesis
- Chromatin Modification
- Cellular Response To Stress
PTMs
- Phosphorylation
- Deacetylation
Research Areas
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBL1X
bosterbio.com/bosterbio-gene-info-cards/TBL1X
References
PMID: 10330347 by Bassi M.T., et al. X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.
PMID: 10809664 by Guenther M.G., et al. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40- repeat protein linked to deafness.