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TBC1D4 Antibodies
AND TBC1D4 ELISA kits, TBC1D4 Proteins
Many biological assays use antibodies to detect TBC1D4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBC1D4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBC1D4 antibodies...
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TBC1D4 Infographic by Boster Bio
All TBC1D4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, IF, IHC
$380
Cat # A02004-2
100ul
Cat # A02004-2
100ul
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02004-3
100 μg/vial
Cat # A02004-3
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M02004
100 µl
Cat # M02004
100 µl
TBC1D4 Overview
Facts about TBC1 domain family member 4.
TBC1 domain family member 4 (TBC1D4)
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14.
Isoform 2 promotes insulin-induced sugar transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake..
Gene Information
| Human | |
|---|---|
| Gene Name: | TBC1D4 |
| Uniprot: | O60343 |
| Entrez: | 9882 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Akt substrate of 160 kDa; AS160Acrg embryonic lethality minimal region ortholog; DKFZp779C0666; KIAA0603TBC (Tre-2, BUB2, CDC16) domain-containing protein; TBC1 domain family member 4; TBC1 domain family, member 4
Molecular Weight
Mass (kDA):
146.563 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q22.2 |
| Sequence: | 13; NC_000013.11 (75283503..75483144, complement) |
Tissue Specificity
Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.
Subcellular Localizations
Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Diseases
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Obesity
- Insulin Sensitivity
- Diabetes Mellitus
- Hyperinsulinism
- Impaired Glucose Tolerance
- Inflammation
- Polycystic Ovary Syndrome
- Malignant Neoplasms
- Neoplasms
- Metabolic Diseases
Interacting Proteins
- YWHAZ
Pathways
- Transport
- Glucose Transport
- Glucose Homeostasis
- Muscle Contraction
- Secretion
- Exocytosis
- Localization
- Endocytosis
- Pathogenesis
- Protein Phosphorylation
- Insulin Secretion
- Vesicle Fusion
- Regulation Of Glucose Transport
PTMs
- Phosphorylation
- Biotinylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBC1D4
bosterbio.com/bosterbio-gene-info-cards/TBC1D4
References
PMID: 18771725 by Baus D., et al. Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells.
PMID: 19077034 by Ishibashi K., et al. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.