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- Table of Contents
Facts about TBC1 domain family member 3.
Acts as a GTPase activating protein for RAB5.
Does not act on RAB4 or RAB11..
Human | |
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Gene Name: | TBC1D3 |
Uniprot: | Q8IZP1 |
Entrez: | 729873 |
Belongs to: |
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No superfamily |
TBC1 domain family member 3
Mass (kDA):
62.187 kDA
Human | |
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Location: | 17q12 |
Sequence: | 17; NC_000017.11 (38181476..38192555, complement) |
Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.
Cell membrane; Lipid-anchor. Associated with lipid rafts.
PMID: 12359748 by Pei L., et al. PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.
PMID: 8471161 by Onno M., et al. Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.