TARBP1 Antibodies

AND TARBP1 ELISA kits, TARBP1 Proteins

Many biological assays use antibodies to detect TARBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TARBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TARBP1 antibodies...

We validate the specificity of these antibodies to TARBP1 by testing them on tissues known to express TARBP1 positively and negatively. Browse below to find the TARBP1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TARBP1 Infographic by Boster Bio

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Anti-TRBP1 TARBP1 Antibody

Human, Mouse

ELISA, WB

$449
Cat # A09397
0.1 mg

TARBP1 Overview

Facts about Probable methyltransferase TARBP1.

TARBP1 3D structure. Source: alphafold

Probable methyltransferase TARBP1 (TARBP1)

Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of disease by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II.

Binding of TARBP1 and RNA polymerase II into HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. May act by methylating HIV-1 TAR RNA.

Gene Information

Human
Gene Name:	TARBP1
Uniprot:	Q13395
Entrez:	6894

Family

Belongs to:

class IV-like SAM-binding methyltransferase superfamily

Alternative Names

EC 2.1.1.-; FLJ30482; TAR (HIV-1) RNA binding protein 1; TAR RNA loop binding protein; TAR RNA-binding protein 1; TAR RNA-binding protein of 185 kDa; tardbp1; TRM3probable methyltransferase TARBP1; TRP-185TAR (HIV) RNA binding protein 1; TRP185TAR (HIV) RNA-binding protein 1

Molecular Weight

Mass (kDA):
181.675 kDA

Genomic Context


Human

Location:	1q42.2
Sequence:	1; NC_000001.11 (234391313..234479179, complement)

Diseases

Hiv Infections
Immunologic Deficiency Syndromes
Neoplasms
Malignant Neoplasms
Basal Cell Carcinoma
Keratosis
Neoplasm Metastasis
Melanoma
Carcinoma
Digeorge Syndrome
Cytomegalovirus Infections
Cell Invasion

Malignant Squamous Cell Neoplasm
Vaccinia
Skin Neoplasms
Malignant Neoplasm Of Skin
Malignant Paraganglionic Neoplasm
Acute Lymphocytic Leukemia

Pathways

Reverse Transcription
Conjugation
Strand Invasion

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TARBP1

References

PMID: 8846792 by Wu-Baer F., et al. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.

PMID: 7638159 by Wu-Baer F., et al. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.