This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
TAOK3 Antibodies
AND TAOK3 ELISA kits, TAOK3 Proteins
Many biological assays use antibodies to detect TAOK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TAOK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TAOK3 antibodies...
Previous: SEPTIN9
Next: KLRF1
TAOK3 Infographic by Boster Bio
All TAOK3 Products
Product
Figures
Specificity
Applications
Price
TAOK3 Overview
Facts about Serine/threonine-protein kinase TAO3.
Serine/threonine-protein kinase TAO3 (TAOK3)
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade.
In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Gene Information
| Human | |
|---|---|
| Gene Name: | TAOK3 |
| Uniprot: | Q9H2K8 |
| Entrez: | 51347 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; DPKJNK/SAPK-inhibitory kinase; EC 2.7.11; FLJ31808; hKFC-A; JIKEC 2.7.11.1; Jun kinase-inhibitory kinase; KDS; Kinase from chicken homolog A; MAP3K18DKFZp666H245; serine/threonine-protein kinase TAO3; STE20-like kinase; TAO kinase 3; Thousand and one amino acid protein 3
Molecular Weight
Mass (kDA):
105.406 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.23 |
| Sequence: | 12; NC_000012.12 (118149801..118372950, complement) |
Tissue Specificity
Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Also localized to the peripheral cell membrane.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Adenoma
- Charcot-marie-tooth Disease
- Charcot-marie-tooth Disease, Axonal, Autosomal Dominant, Type 2l
- Colonic Neoplasms
- Parkinson Disease
Interacting Proteins
- ERN1
- TRAF2
Pathways
- Response To Oxidative Stress
- Neuronal Signal Transduction
- Viral Replication
PTMs
Research Areas
- Cell Biology
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAOK3
bosterbio.com/bosterbio-gene-info-cards/TAOK3
References
PMID: 10559204 by Tassi E., et al. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor.
PMID: 10924369 by Zhang W., et al. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways.