Serglycin Antibodies

AND SRGN ELISA kits, Serglycin Proteins

Many biological assays use antibodies to detect Serglycin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serglycin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serglycin antibodies...

We validate the specificity of these antibodies to Serglycin by testing them on tissues known to express SRGN positively and negatively. Browse below to find the SRGN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SRGN Infographic by Boster Bio

All SRGN Products

Product

Figures

Specificity

Applications

Price

Anti-Serglycin SRGN Antibody

Human, Mouse

$405
Cat # A06069
100ul

SRGN Human, Serglycin Human Recombinant Protein, HEK

Human

$250
Cat # PROTP10124
2ug, 10ug, 1mg

Serglycin (SRGN) (NM_002727) Human Over-expression Lysate

Human

$628
Cat # LS005552
100 µg

SRGN Overview

Facts about Serglycin.

SRGN 3D structure. Source: alphafold

Serglycin (SRGN)

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in the connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes.

Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B that's delivered to cells by perforin to cause apoptosis.

Gene Information

Human
Gene Name:	SRGN
Uniprot:	P10124
Entrez:	5552

Family

Belongs to:

serglycin family

Alternative Names

FLJ12930; Hematopoetic proteoglycan core protein; MGC9289; P.PG; Platelet proteoglycan core protein; platelet proteoglycan protein core; PPG; PRG1p.PG; PRGhematopoetic proteoglycan core peptide; proteoglycan 1, secretory granule; proteoglycan protein core for mast cell secretory granule; secretory granule proteoglycan 1; secretory granule proteoglycan core peptide; Secretory granule proteoglycan core protein; serglycin proteoglycan; Serglycin; SRGN

Molecular Weight

Mass (kDA):
17.652 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (69057533..69104811)

Subcellular Localizations

Cytoplasmic granule. Secreted, extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).

Diseases

Carcinoma
Neoplasms
Neoplasm Metastasis
Neoplasm Invasiveness
Acquired Immunodeficiency Syndrome
Metastatic Malignant Neoplasm To The Liver
Communicable Diseases
Head And Neck Carcinoma
Inflammatory Response
Familial Hemophagocytic Lymphocytosis
Head And Neck Neoplasms
Renal Cell Carcinoma

Cell Invasion
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Pneumocystis Infections
Primary Neoplasm
Malignant Paraganglionic Neoplasm
Lymphohistiocytosis, Hemophagocytic

Interacting Proteins

GZMB
SGTA
UBQLN1

Pathways

Secretion
Regeneration
Secretory Pathway
Tissue Regeneration
Phagocytosis
Cell Death
Anoikis
Immune Response
Glycosylation

Regulated Secretory Pathway
Humoral Immune Response
Inflammatory Response

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRGN

References

PMID: 2835370 by Stevens R.L., et al. Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells.

PMID: 2798108 by Stellrecht C.M., et al. Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein.