Bone marrow proteoglycan Antibodies

AND PRG2 ELISA kits, Bone marrow proteoglycan Proteins

Many biological assays use antibodies to detect Bone marrow proteoglycan, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bone marrow proteoglycan in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bone marrow proteoglycan antibodies...

We validate the specificity of these antibodies to Bone marrow proteoglycan by testing them on tissues known to express PRG2 positively and negatively. Browse below to find the PRG2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRG2 Infographic by Boster Bio

All PRG2 Products

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Anti-Major Basic Protein (PRG2) Mouse Monoclonal Antibody [Clone ID: OTI2F11]

Human

$523
Cat # M03953
100 µl

Major Basic Protein (PRG2) (NM_002728) Human Over-expression Lysate

Human

$628
Cat # LS005553
100 µg

PRG2 Overview

Facts about Bone marrow proteoglycan.

PRG2 3D structure. Source: alphafold

Bone marrow proteoglycan (PRG2)

Cytotoxin and helminthotoxin.
Additionally induces non-cytolytic histamine release from human basophils.

Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Information

Human
Gene Name:	PRG2
Uniprot:	P13727
Entrez:	5553

Family

Belongs to:

No superfamily

Alternative Names

BMPG; BMPGeosinophil major basic protein; bone marrow proteoglycan; bone-marrow proteoglycan; EMBP; MBP1; MBP-1; MBPeosinophil granule major basic protein; MGC14537; natural killer cell activator; PRG2; proteoglycan 2 preproprotein; Proteoglycan 2; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granulemajor basic protein)

Molecular Weight

Mass (kDA):
25.206 kDA

Genomic Context


Human

Location:	11q12.1
Sequence:	11; NC_000011.10 (57386780..57390650, complement)

Tissue Specificity

High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Subcellular Localizations

[Bone marrow proteoglycan]: Secreted. The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

Diseases

Eosinophilia
Hypertension Induced By Pregnancy
Hypertensive Disease
Down Syndrome
Malignant Neoplasms
Myeloid Leukemia
Sinusitis
Inflammation
Pre-eclampsia
Asthma
Dental Plaque
Chronic Sinusitis

Pregnancy Complications, Cardiovascular
Hypereosinophilic Syndrome
Keratoconjunctivitis
Pregnancy Complications
Polyps
Malignant Tumor Of Colon

Pathways

Localization
Drug Resistance
Pathogenesis
Secretion
Transport
Intracellular Transport
Immune System Process
Glycosylation
Proteolysis

Superoxide Anion Generation
Neutrophil Activation
Methylation
System Process

PTMs

Demethylation

Cleavage

Methylation

Research Areas

Asthma
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRG2

References

PMID: 3171483 by Barker R.L., et al. Acidic precursor revealed in human eosinophil granule major basic protein cDNA.

PMID: 2323577 by Barker R.L., et al. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein.