SRD5A2 Antibodies

AND SRD5A2 ELISA kits, SRD5A2 Proteins

Many biological assays use antibodies to detect SRD5A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRD5A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRD5A2 antibodies...

We validate the specificity of these antibodies to SRD5A2 by testing them on tissues known to express SRD5A2 positively and negatively. Browse below to find the SRD5A2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SRD5A2 Infographic by Boster Bio

All SRD5A2 Products

Product

Figures

Specificity

Applications

Price

Anti-S5A2 SRD5A2 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A00704
100ul

Anti-SRD5A2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, WB

$370
Cat # M00704
100 μl/vial

SRD5A2 Overview

Facts about 3-oxo-5-alpha-steroid 4-dehydrogenase 2.

SRD5A2 3D structure. Source: alphafold

3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Gene Information

Human
Gene Name:	SRD5A2
Uniprot:	P31213
Entrez:	6716

Family

Belongs to:

steroid 5-alpha reductase family

Alternative Names

3-oxo-5-alpha-steroid 4-dehydrogenase 2,5 alpha-SR2; EC 1.3.99.5; MGC138457; S5AR 2; SR type 2; Steroid 5-alpha-reductase 2,3-oxo-5 alpha-steroid 4-dehydrogenase 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta4-dehydrogenase alpha 2); Type II 5-alpha reductase

Molecular Weight

Mass (kDA):
28.393 kDA

Genomic Context


Human

Location:	2p23.1
Sequence:	2; NC_000002.12 (31522480..31665651, complement)

Tissue Specificity

Expressed in high levels in the prostate and many other androgen-sensitive tissues.

Subcellular Localizations

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Disorders Of Sex Development
Neoplasms
Hypospadias
Prostatic Hyperplasia
Virilism
Benign Prostatic Hypertrophy
Hyperplasia
Ambiguous Genitalia
Pseudohermaphroditism Male

Testicular Feminization
46, Xy Disorders Of Sex Development
Malignant Neoplasm Of Breast
Carcinogenesis
Mammary Neoplasms
Reifenstein Syndrome
Penis Agenesis

Pathways

Cell Proliferation
Spermatogenesis
Sex Differentiation
Pathogenesis
Dna Repair
Transport
Aging
Localization
Methylation
Cell Division
Sperm Motility
Cell Growth
Secretion

Brain Development
Neurogenesis
Sex Determination
Leydig Cell Differentiation
Reflex
Prostatic Bud Formation
Translation

PTMs

Methylation
Cleavage

Farnesylation
Acetylation

Deglycosylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRD5A2

References

PMID: 1944596 by Andersson S., et al. Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.

PMID: 1505484 by Labrie F., et al. Structure of human type II 5 alpha-reductase gene.