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- Table of Contents
Facts about Steroid receptor RNA activator 1.
Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.
Human | |
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Gene Name: | SRA1 |
Uniprot: | Q9HD15 |
Entrez: | 10011 |
Belongs to: |
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SRA1 family |
MGC87674; pp7684; SRA; SRAP; steriod receptor RNA activator 1; steriod receptor RNA activator protein; steroid receptor coactivator; steroid receptor RNA activator 1 (complexes with NCOA1); steroid receptor RNA activator 1; Steroid receptor RNA activator protein; STRAA1
Mass (kDA):
25.673 kDA
Human | |
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Location: | 5q31.3 |
Sequence: | 5; NC_000005.10 (140550067..140558093, complement) |
Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus.
Nucleus. Cytoplasm.
PMID: 12565891 by Emberley E., et al. Identification of new human coding steroid receptor RNA activator isoforms.
PMID: 10199399 by Lanz R.B., et al. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.