SPTLC2 Antibodies

AND SPTLC2 ELISA kits, SPTLC2 Proteins

Many biological assays use antibodies to detect SPTLC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTLC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTLC2 antibodies...

We validate the specificity of these antibodies to SPTLC2 by testing them on tissues known to express SPTLC2 positively and negatively. Browse below to find the SPTLC2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPTLC2 Infographic by Boster Bio

All SPTLC2 Products

Product

Figures

Specificity

Applications

Price

Anti-SPT2 SPTLC2 Antibody

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A05504
0.1 mg

Serine Palmitoyltransferase (SPTLC2) (NM_004863) Human Over-expression Lysate

Human

$628
Cat # LS009517
100 µg

SPTLC2 Overview

Facts about Serine palmitoyltransferase 2.

SPTLC2 3D structure. Source: alphafold

Serine palmitoyltransferase 2 (SPTLC2)

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core.

The composition of this serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex indicates a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.

Gene Information

Human
Gene Name:	SPTLC2
Uniprot:	O15270
Entrez:	9517

Family

Belongs to:

class-II pyridoxal-phosphate-dependent aminotransferase family

Alternative Names

EC 2.3.1; EC 2.3.1.50; KIAA0526HSN1C; LCB 2; LCB2A; LCB2NSAN1C; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; serine palmitoyltransferase 2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase, subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2

Molecular Weight

Mass (kDA):
62.924 kDA

Genomic Context


Human

Location:	14q24.3
Sequence:	14; NC_000014.9 (77505997..77616663, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Hereditary Sensory And Autonomic Neuropathies
Sensory Neuropathy, Hereditary
Sensory Neuropathy
Malignant Neoplasms
Hereditary Sensory Autonomic Neuropathy, Type 1
Neoplasms
Chimera Disorder
Absence Of Sensation
Atherosclerosis
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Carcinoma

Abnormal Degeneration
Hereditary Diseases
Malignant Paraganglionic Neoplasm
Peripheral Neuropathy
Degenerative Disorder
Dermatitis, Atopic
Dermatitis, Phototoxic

Pathways

Cell Death
Cell Proliferation
Keratinocyte Differentiation
Localization
Cholesterol Efflux
Pathogenesis
Secretion
Transport
Neural Tube Closure
Cell Migration
Cellular Homeostasis
Glycosylation

Proteolysis
Tropism
Myelination
Tube Closure
Tissue Remodeling
Cholesterol Homeostasis

PTMs

Cleavage
Glycosylation

Decarboxylation
Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTLC2

References

PMID: 9363775 by Weiss B., et al. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis.

PMID: 8921873 by Nagiec M.M., et al. Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase.