Osteopontin Antibodies

Osteopontin (SPP1)

Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix.

Probably important to cell-matrix interaction. .

Gene Information

Human
Gene Name:	SPP1
Uniprot:	P10451
Entrez:	6696

Family

Belongs to:
osteopontin family

Alternative Names

BNSP; Bone sialoprotein 1; Eta-1; MGC110940; Nephropontin; OPN; Osteopontin; secreted phosphoprotein 1bone sialoprotein I, early T-lymphocyteactivation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein); Spp1; SPP-1; SPP1/CALPHA1 fusion; Urinary stone protein; uropontin

Molecular Weight

Mass (kDA):
35.423 kDA

Genomic Context

Human
Location:	4q22.1
Sequence:	4; NC_000004.12 (87975650..87983411)

Tissue Specificity

Bone. Found in plasma.

Subcellular Localizations

Secreted.

Diseases

• Neoplasms
• Tissue Adhesions
• Malignant Neoplasms
• Neoplasm Metastasis
• Inflammation
• Carcinoma
• Fibrosis
• Calcinosis
• Cell Invasion
• Kidney Diseases
• Cell Transformation, Neoplastic
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Breast

• Hypertrophy
• Osteosarcoma
• Tumor Angiogenesis
• Mammary Neoplasms
• Atherosclerosis
• Hyperplasia
• Tumor Progression

Interacting Proteins

• CD44
• FAM20C
• MEOX2
• SGTA

Pathways

• Cell Adhesion
• Cell Proliferation
• Localization
• Pathogenesis
• Secretion
• Osteoblast Differentiation
• Bone Resorption
• Cell Migration
• Regeneration
• Angiogenesis
• Cell Growth
• Bone Remodeling
• Cell Differentiation

• Wound Healing
• Ossification
• Cell Death
• Inflammatory Response
• Chemotaxis
• Excretion
• Immune Response

PTMs

• Phosphorylation
• Cleavage
• Glycosylation
• Methylation
• Dephosphorylation
• Acetylation
• Sulphation
• Nitrosylation

• Hydroxylation
• Ubiquitination
• Iodination
• Nitration
• Biotinylation
• Citrullination
• Ribosylation
• Amination

• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPP1

Boster Biomarkers - The Best Uses Of The SPP1 Marker

Osteopontin is a protein encoded in the SPP1 genes. The SPP1 gene is widely used in immunohistochemistry. We'll talk about the benefits of Osteopontin Biomarkers, how they can be used and what the future holds for them. Let's start with some basic information. Osteopontin is a biomarker, which means that it can be used for immunohistochemistry.

Osteopontin is an encoded protein in the SPP1 gene.

OPN is a part of bone. OPN is also known by numerous other names like bone sialoprotein, and early T-lymphocyte activation. It also secretes phosphoprotein 1 as well as 2ar. Its primary function in the cardiovascular system is to regulate cell adhesion as well as synthesis of collagen. It also plays a significant role in the process of remodeling of the heart.

This ECM protein binds to various Integrin receptors, and plays a role in adhesion and the migration of immune cells. It has been demonstrated to stop the progression of cancer. It also hinders macrophages' movement away from brain accumulation locations. It has been linked with a variety of biological processes such as angiogenesis, inflammation and immunity.

The SPP1 gene is located on chromosome 4q22.1. Osteopontin is most commonly expressed in the gall bladder and placenta, but it can also be found in other tissues. It is related to the Integrin Pathway, Development-Hedgehog, and PTH signaling pathways. In addition this gene is involved in extracellular matrix binding and is associated with a range of disorders.

In addition to stimulating the production of corticosterone, osteopontin also aids in the development of immune cells. In mice with osteopontin-deficient phenotype, osteopontin expression is decreased while that of wild-type mice increases. Osteopontin also blocks IL-10. Osteopontin may thus be a possible target for blocking the progression of MS.

Osteopontin is an inherited gene that encodes an molecule called Osteopontin. It is a major factor in the prevention and treatment for breast cancer. Osteopontin has a high degree of resistance to tamoxifen and will cause an increase of 30% in patients suffering from this type of.

Ostepontin has been found to reduce the risk of esophageal tumors. It also blocks the formation of Barrett's esophageal cancer. A study by Wang et al. has revealed that the SPP1 gene is commonly upregulated in patients with Barrett's esophageal dysplasia.

It is a biomarker

A biomarker test is a method used to detect certain types of cancer. SPP1 (secreted phosphoprotein 1) is a biomarker of lung cancer called adenocarcinoma. Elsevier publishes SPP1. It is a prognostic marker for patients suffering from stage T1 (or stage N0) or N1 disease. Although it isn't yet widely utilized in clinical trials, it is a promising biomarker.

It is employed in immunohistochemistry.

The osteopontin protein (or SPP1) is a highly expressed femur glycoprotein which bonds with high affinity to hydroxyapatite. This protein is likely to be a target for the osteoclast vitronectin receptor that is located on the cell membrane. It is also involved in the regulation of interferon-gamma and interleukin-12. There are many transcript variants of the gene that encodes this protein. Boster tests its antibodies on various platforms to ensure optimal performance.