SPDEF Antibodies

AND SPDEF ELISA kits, SPDEF Proteins

Many biological assays use antibodies to detect SPDEF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPDEF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPDEF antibodies...

We validate the specificity of these antibodies to SPDEF by testing them on tissues known to express SPDEF positively and negatively. Browse below to find the SPDEF antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPDEF Infographic by Boster Bio

All SPDEF Products

Product

Figures

Specificity

Applications

Price

Anti-SPDEF Antibody

Human, Rat

IF, IHC, ICC, WB

$405
Cat # A04625
100ul

SPDEF (NM_012391) Human Recombinant Protein

$1249
Cat # PROTO95238
20 µg

SPDEF (NM_012391) Human Over-expression Lysate

Human

$628
Cat # LS025803
100 µg

Anti-PSE/SPDEF Antibody Picoband™

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04625-1
100 µg/vial

SPDEF Overview

Facts about SAM pointed domain-containing Ets transcription factor.

SPDEF 3D structure. Source: alphafold

SAM pointed domain-containing Ets transcription factor (SPDEF)

May be the androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences.

May play a role in the regulation of the prostate gland or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.

Gene Information

Human
Gene Name:	SPDEF
Uniprot:	O95238
Entrez:	25803

Family

Belongs to:

ETS family

Alternative Names

bA375E1.3; PDEFRP11-375E1__A.3; Prostate epithelium-specific Ets transcription factor; Prostate-derived Ets factor; Prostate-specific Ets; PSE; SAM pointed domain containing ets transcription factor; SAM pointed domain-containing Ets transcription factor

Molecular Weight

Mass (kDA):
37.518 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (34537800..34556333, complement)

Tissue Specificity

Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Breast
Prostatic Neoplasms
Cell Invasion
Malignant Neoplasm Of Prostate
Neoplasm Metastasis
Lung Diseases
Metaplasia
Neoplasm Invasiveness
Asthma

Carcinoma
Lung Diseases, Obstructive
Inflammation
Chronic Obstructive Airway Disease
Hyperplasia
Tumor Progression
Cell Transformation, Neoplastic

Pathways

Cell Growth
Cell Cycle
Cell Differentiation
Cell Proliferation
Pathogenesis
Cell Migration
Secretion
Sensitization
Cell Adhesion
Mucus Secretion
Cytoskeleton Organization
Induction Of Apoptosis
Glycosylation

Angiogenesis
Transport
Gene Silencing
Cellular Homeostasis
Aging
Lung Development
Hypersensitivity

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPDEF

References

PMID: 10675039 by Yamada N., et al. Cloning and expression of the mouse Pse gene encoding a novel Ets family member.

PMID: 10625666 by Oettgen P., et al. PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.