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Sclerostin Antibodies
AND SOST ELISA kits, Sclerostin Proteins
Many biological assays use antibodies to detect Sclerostin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sclerostin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sclerostin antibodies...
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SOST Infographic by Boster Bio
All SOST Products
Product
Figures
Specificity
Applications
Price
Rat
ELISA
$499
Cat # EK1565
96 wells/kit, with removable strips.
Cat # EK1565
96 wells/kit, with removable strips.
Mouse Sclerostin/SOST ELISA Kit PicoKine®
3 Citations 9 Q&As
Mouse
ELISA
$399
Cat # EK1179
96 wells/kit, with removable strips.
Cat # EK1179
96 wells/kit, with removable strips.
Human Sclerostin/SOST ELISA Kit PicoKine®
3 Citations 10 Q&As
Human
ELISA
$499
Cat # EK0968
96 wells/kit, with removable strips.
Cat # EK0968
96 wells/kit, with removable strips.
SOST Overview
Facts about Sclerostin.
Sclerostin (SOST)
Negative regulator of bone development that acts through inhibition of Wnt signaling and bone formation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SOST |
| Uniprot: | Q9BQB4 |
| Entrez: | 50964 |
Family
| Belongs to: |
|---|
| sclerostin family |
Alternative Names
sclerostin; SOST; VBCHsclerosteosis
Molecular Weight
Mass (kDA):
24.031 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (43753738..43758791, complement) |
Tissue Specificity
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Osteoporosis
- Fracture
- Bone Diseases
- Osteopenia
- Osteoporosis, Postmenopausal
- Van Buchem Disease
- Bone Diseases, Developmental
- Hyperostosis
- Dysplasia
- Osteosclerosis
- Osteoporotic Fractures
- Syndactyly
Interacting Proteins
- LRP4
- LRP5
- LRP6
Pathways
- Bone Resorption
- Bone Remodeling
- Osteoblast Differentiation
- Pathogenesis
- Secretion
- Regeneration
- Osteoclast Differentiation
- Aging
- Localization
- Bone Development
- Bone Mineralization
- Ossification
- Regulation Of Bone Remodeling
PTMs
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOST
bosterbio.com/bosterbio-gene-info-cards/SOST
References
PMID: 11181578 by Balemans W., et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).
PMID: 11179006 by Brunkow M.E., et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.
5 Publications of Boster Sclerostin Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0167312, Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement
- PubMed ID: 10.1016/j.colsurfb.2018.12.023, Regulation of osteoblast differentiation by osteocytes cultured on sclerostin an...
- PubMed ID: -, WANG,ENZHI,LIN,JIANJUN,XU,GUANGWEI,WANG,XINHUA,&CHEN, MIFANG.(2020). EFFECT OF P...
- PubMed ID: 33159796, Mishra D,Dhir V,Naidu GSRSNK,Khullar A,Kumar V,Sharma S,Sharma A,Jain S. Efficac...
- PubMed ID: 28081119, Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement
*More publications can be found for each product on its corresponding product page