SMPD1 Antibodies

AND SMPD1 ELISA kits, SMPD1 Proteins

Many biological assays use antibodies to detect SMPD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMPD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMPD1 antibodies...

We validate the specificity of these antibodies to SMPD1 by testing them on tissues known to express SMPD1 positively and negatively. Browse below to find the SMPD1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMPD1 Infographic by Boster Bio

All SMPD1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human SMPD1 ELISA Kit PicoKine®

7 Q&As

Human

ELISA

$499
Cat # EK2025
96 wells/kit, with removable strips.

Anti-ASM SMPD1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A00752
100ul

Anti-Acid sphingomyelinase (SMPD1) Mouse Monoclonal Antibody [Clone ID: OTI3H7]

+19

Human

IHC, WB

$560
Cat # M00752
100 µl

Anti-Smpd1 Antibody Picoband®

Mouse, Rat

ELISA, WB

$370
Cat # A00752-1
100 μg/vial

Acid sphingomyelinase (SMPD1) (NM_000543) Human Over-expression Lysate

Human

$960
Cat # LS006609
100 µg

SMPD1 Overview

Facts about Sphingomyelin phosphodiesterase.

SMPD1 3D structure. Source: alphafold

Sphingomyelin phosphodiesterase (SMPD1)

Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.

Gene Information

Human
Gene Name:	SMPD1
Uniprot:	P17405
Entrez:	6609

Family

Belongs to:

acid sphingomyelinase family

Alternative Names

Acid sphingomyelinase; aSMase; ASMsphingomyelin phosphodiesterase; EC 3.1.4.12; NPD; SMPD1; sphingomyelin phosphodiesterase 1, acid lysosomal

Molecular Weight

Mass (kDA):
69.936 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (6390474..6394998)

Subcellular Localizations

Lysosome. Secreted.

Diseases

Niemann-pick Diseases
Aggressive Systemic Mastocytosis
Niemann-pick Disease, Type B
Niemann-pick Disease, Type A
Neoplasms
Malignant Neoplasms
Pick Disease Of The Brain
Beckwith-wiedemann Syndrome
Ataxia
Inflammation
Coronary Artery Disease
Congenital Hemihypertrophy

Tangier Disease
Nerve Degeneration
Niemann-pick Disease, Type C
Metabolic Diseases
Malnutrition
Mutation, Out-of-frame
Embryonal Carcinoma

Interacting Proteins

CASP7

Pathways

Cell Death
Lipid Storage
Localization
Cholesterol Efflux
Vasodilation
Regulation Of Growth
Neurogenesis
Metaphase
Keratinocyte Differentiation
Membrane Fusion
Decidualization
Regeneration

Translation
Embryo Implantation
Phospholipid Efflux
Pathogenesis
Rna Interference
Protein Processing
Secretion

PTMs

Cleavage

Phosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMPD1

References

PMID: 1840600 by Schuchman E.H., et al. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs.

PMID: 1292508 by Newrzella D., et al. Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene.