Sphingomyelin phosphodiesterase 2 (SMPD2)

Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating variable ).

The physiological substrate appears to be Lyso-PAF. .