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SLC3A2 Antibodies
AND SLC3A2 ELISA kits, SLC3A2 Proteins
Many biological assays use antibodies to detect SLC3A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC3A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC3A2 antibodies...
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SLC3A2 Infographic by Boster Bio
All SLC3A2 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01794-3
100 μg/vial
Cat # A01794-3
100 μg/vial
SLC3A2 Overview
Facts about 4F2 cell-surface antigen heavy chain.
4F2 cell-surface antigen heavy chain (SLC3A2)
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan.
Involved in directing and targeting of LAT1 and LAT2 into the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC3A2 |
| Uniprot: | P08195 |
| Entrez: | 6520 |
Family
| Belongs to: |
|---|
| SLC3A transporter family |
Alternative Names
4F2; 4F2hc; 4T2HC; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC; CD98 antigen; CD98 heavy chain; CD98; CD98HC; CH98hc; FRP-1; heavy chain; Lymphocyte activation antigen 4F2 large subunit; MDU1antigen defined by monoclonal 4F2, heavy chain; monoclonal 44D7; NACAE4F2 cell-surface antigen heavy chain; SLC3A2; solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen
Molecular Weight
Mass (kDA):
67.994 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.3 |
| Sequence: | 11; NC_000011.10 (62856109..62888860) |
Tissue Specificity
Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid- trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.
Subcellular Localizations
Apical cell membrane. Cell membrane; Single-pass type II membrane protein. Cell junction. Lysosome membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localized at the plasma membrane when associated with SLC7A5 or SLC7A8 (PubMed:9751058, PubMed:11311135). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). Located selectively at cell-cell adhesion sites (By similarity). Colocalized with SLC7A8/LAT2 at the basolateral membrane of ki
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Carcinoma
- Diabetes Mellitus
- Malignant Tumor Of Colon
- Adenocarcinoma
- Liver Carcinoma
- Autoimmune Diseases
- Diabetes Mellitus, Insulin-dependent
- Colonic Neoplasms
- Malignant Neoplasm Of Lung
Interacting Proteins
- GPR37
- SLC7A5
Pathways
- Transport
- Amino Acid Transport
- Cell Proliferation
- Arginine Transport
- Neutral Amino Acid Transport
- Localization
- Cell Growth
- Pathogenesis
- Cell Activation
- Immune Response
- Translation
- Cell Cycle
- T Cell Proliferation
PTMs
- Phosphorylation
- Carboxylation
Research Areas
- Cell Biology
- Cellular Markers
- Immunology
- Lipid and Metabolism
- Plasma Membrane Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC3A2
bosterbio.com/bosterbio-gene-info-cards/SLC3A2
References
PMID: 3476959 by Quackenbush E., et al. Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.
PMID: 3036867 by Teixeira S., et al. Primary structure of the human 4F2 antigen heavy chain predicts a transmembrane protein with a cytoplasmic NH2 terminus.