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- Table of Contents
Facts about Zinc transporter ZIP5.
Could modulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status.
Mouse | |
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Gene Name: | Slc39a5 |
Uniprot: | Q9D856 |
Entrez: | 72002 |
Belongs to: |
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ZIP transporter (TC 2.A.5) family |
LZT-Hs7; MGC34778; solute carrier family 39 (metal ion transporter), member 5; Solute carrier family 39 member 5; zinc transporter ZIP5; ZIP5; ZIP-5; Zrt- and Irt-like protein 5
Mass (kDA):
56.275 kDA
Mouse | |
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Location: | 10|10 D3 |
Sequence: | 10; |
Expressed in all stages of eye development and primarily in the sclera and several layers of the retina, including the inner segment, outer plexiform layer and ganglion cell layer.
PMID: 15322118 by Wang F., et al. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells.
PMID: 24891338 by Guo H., et al. SLC39A5 mutations interfering with the BMP/TGF-beta pathway in non- syndromic high myopia.