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- Table of Contents
1 Citations 2 Q&As
1 Citations 6 Q&As
Facts about Solute carrier family 2, facilitated glucose transporter member 5.
Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose.
Human | |
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Gene Name: | SLC2A5 |
Uniprot: | P22732 |
Entrez: | 6518 |
Belongs to: |
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major facilitator superfamily |
Fructose transporter; Glucose transporter type 5, small intestine; Glut5; GLUT-5; GLUT5glucose transporter-like protein 5; SLC2A5; solute carrier family 2 (facilitated glucose transporter), member 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5; solute carrier family 2, facilitated glucose transporter member 5
Mass (kDA):
54.974 kDA
Human | |
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Location: | 1p36.23 |
Sequence: | 1; NC_000001.11 (9035106..9072259, complement) |
Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.
PMID: 8037665 by Mahraoui L., et al. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.
PMID: 8333543 by Rand E.B., et al. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5.
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