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- Table of Contents
Facts about Solute carrier family 22 member 8.
Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). .
Human | |
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Gene Name: | SLC22A8 |
Uniprot: | Q8TCC7 |
Entrez: | 9376 |
Belongs to: |
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major facilitator (TC 2.A.1) superfamily |
hOAT3; MGC24086; OAT3Organic anion transporter 3; solute carrier family 22 (organic anion transporter), member 8; solute carrier family 22 member 8
Mass (kDA):
59.856 kDA
Human | |
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Location: | 11q12.3 |
Sequence: | 11; NC_000011.10 (62992824..63015845, complement) |
Expressed in kidney.
Basolateral cell membrane; Multi-pass membrane protein. Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity).
PMID: 10049739 by Race J.E., et al. Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).
PMID: 11912245 by Motohashi H., et al. Gene expression levels and immunolocalization of organic ion transporters in the human kidney.