SIPA1 Antibodies

AND SIPA1 ELISA kits, SIPA1 Proteins

Many biological assays use antibodies to detect SIPA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIPA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIPA1 antibodies...

We validate the specificity of these antibodies to SIPA1 by testing them on tissues known to express SIPA1 positively and negatively. Browse below to find the SIPA1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIPA1 Infographic by Boster Bio

All SIPA1 Products

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Anti-Sipa1 Antibody

4 Q&As

Human, Mouse

ELISA, IHC, WB

$629
Cat # A05549
100ug

SIPA1 Overview

Facts about Signal-induced proliferation-associated protein 1.

SIPA1 3D structure. Source: alphafold

Signal-induced proliferation-associated protein 1 (SIPA1)

GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state (PubMed:9346962). Affects cell cycle progression (By similarity).

Gene Information

Human
Gene Name:	SIPA1
Uniprot:	Q96FS4
Entrez:	6494

Family

Belongs to:

No superfamily

Alternative Names

GTPase-activating protein Spa-1; MGC102688; MGC17037; p130 SPA-1; signal-induced proliferation-associated 1; signal-induced proliferation-associated protein 1; sipa-1; SPA1signal-induced proliferation-associated gene 1

Molecular Weight

Mass (kDA):
112.149 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (65638101..65650930)

Tissue Specificity

Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.

Subcellular Localizations

Nucleus. Cytoplasm, perinuclear region. Endomembrane system; Peripheral membrane protein. Mostly localized in the perinuclear membraneous region.

Diseases

Malignant Neoplasms
Neoplasm Metastasis
Neoplasms
Malignant Neoplasm Of Breast
Leukemia
Mammary Neoplasms
Tissue Adhesions
Myeloid Leukemia
Cell Invasion
Myeloproliferative Disease
Myeloid Leukemia, Chronic
Lymphatic Metastasis

Immunologic Deficiency Syndromes
Tumor Progression
Blast Phase
Metastatic Malignant Neoplasm To The Lymph Node
Metastatic Malignant Neoplasm To The Lung
Neoplasm Invasiveness
Malignant Tumor Of Cervix

Interacting Proteins

CDKN1A

Pathways

Cell Adhesion
Cell Death
Cell Cycle
Cell Division
Localization
Cell Growth
Cell Activation
Cell Migration
T Cell Activation
Leukocyte Migration
Translation
Protein Geranylgeranylation
Regulation Of T Cell Activation

Interphase
Interleukin-2 Production
Lymphocyte Proliferation
Oncogenesis
Actin Cytoskeleton Reorganization
Cell Proliferation
Cell Development

PTMs

Phosphorylation

Farnesylation

Geranylgeranylation

Research Areas

Apoptosis
Breast Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIPA1

References

PMID: 9346962 by Kurachi H., et al. Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2.

PMID: 9651531 by Ebrahimi S., et al. Genomic organization and cloning of the human homologue of murine Sipa-1.