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- Table of Contents
Facts about Histone-lysine N-methyltransferase SETD7.
Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription.
Mouse | |
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Gene Name: | Setd7 |
Uniprot: | Q8VHL1 |
Entrez: | 73251 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
EC 2.1.1.43; H3-K4-HMTase SETD7; histone H3-lysine 4-specific methyltransferase; histone-lysine N-methyltransferase SETD7; KIAA1717SET domain-containing protein 7; KMT7FLJ21193; Lysine N-methyltransferase 7; SET domain containing (lysine methyltransferase) 7; SET7/9Histone H3-K4 methyltransferase SETD7; SET7Set9; SET9
Mass (kDA):
40.506 kDA
Mouse | |
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Location: | 3|3 C |
Sequence: | 3; |
PMID: 11779497 by Wang H., et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
PMID: 12711597 by Chakrabarti S.K., et al. Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.