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- Table of Contents
, No Gclids
Protein SET Antibodies
AND SET ELISA kits, Protein SET Proteins
Many biological assays use antibodies to detect Protein SET, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein SET in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein SET antibodies...
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SET Infographic by Boster Bio
All SET Products
Product
Figures
Specificity
Applications
Price
Anti-SET Monoclonal Antibody
6 Q&As
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02211
100 μl
Cat # M02211
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A02211-1
100ul
Cat # A02211-1
100ul
SET Overview
Facts about Protein SET.
Protein SET (SET)
Isoform 2 anti-apoptotic action is mediated by inhibition of the GZMA-activated DNase, NME1. In the class of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, interrupting its binding to NME1 and releasing NME1 inhibition.
Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most likely by masking the accessibility of lysines of histones to the acetylases.
Gene Information
| Human | |
|---|---|
| Gene Name: | SET |
| Uniprot: | Q01105 |
| Entrez: | 6418 |
Family
| Belongs to: |
|---|
| nucleosome assembly protein (NAP) family |
Alternative Names
2PP2A; HLA-DR-associated protein II; I2PP2A; I-2PP2A; IGAAD; Inhibitor of granzyme A-activated DNase; inhibitor-2 of protein phosphatase-2A; IPP2A2; PHAPIITAF-I; Phosphatase 2A inhibitor I2PP2A; protein phosphatase type 2A inhibitor; protein SET; SET nuclear oncogene; SET translocation (myeloid leukemia-associated); TAF-IBETA; Template-activating factor I; Template-Activating Factor-I, chromatin remodelling factor
Molecular Weight
Mass (kDA):
33.489 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.11 |
| Sequence: | 9; NC_000009.12 (128683424..128696396) |
Tissue Specificity
Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor.
Subcellular Localizations
Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium.
Diseases
- Leukemia
- Neoplasms
- Myeloid Leukemia
- Malignant Neoplasms
- Acute Undifferentiated Leukemia
- Leukemia, Myelocytic, Acute
- Leukemogenesis
- Alzheimer's Disease
- Chromosomal Translocation
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Acute Lymphocytic Leukemia
- Carcinoma
- Cell Transformation, Neoplastic
Interacting Proteins
- FAM111B
- FOXO1
- MDM2
- MEOX2
- PRKAR1A
- RAC1
- SDCBP
- TAF1A
- TAF1B
- TAF1C
Pathways
- Cell Cycle
- Localization
- Nucleosome Assembly
- Dna Replication
- Cell Death
- Cell Proliferation
- Histone Acetylation
- Chromatin Remodeling
- Methylation
- Pathogenesis
- Chromatin Assembly
- Transport
- Hyperphosphorylation
PTMs
- Phosphorylation
- Acetylation
- Cleavage
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SET
bosterbio.com/bosterbio-gene-info-cards/SET
References
PMID: 1630450 by von Lindern M., et al. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.
PMID: 8192856 by Vaesen M., et al. Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII.