Heparin cofactor 2 Antibodies

Heparin cofactor 2 (SERPIND1)

Thrombin inhibitor activated from the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III).

Also inhibits chymotrypsin, but in a glycosaminoglycan-independent method. .

Gene Information

Human
Gene Name:	SERPIND1
Uniprot:	P05546
Entrez:	3053

Family

Belongs to:
serpin family

Alternative Names

HC2; HC2LS2; HCF2; HCF2clade D (heparin cofactor), member 1; HC-II; Heparin Cofactor II; HLS2HCII; leuserpin 2; LS2; Protease inhibitor leuserpin-2; Serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Molecular Weight

Mass (kDA):
57.071 kDA

Genomic Context

Human
Location:	22q11.21
Sequence:	22; NC_000022.11 (20774113..20787720)

Tissue Specificity

Expressed predominantly in liver. Also present in plasma.

Diseases

• Atherosclerosis
• Cardiovascular Diseases
• Malignant Neoplasms
• Dental Plaque
• Blood Coagulation Disorders
• Thrombosis
• Schizoaffective Disorder
• Neoplasm Metastasis
• Infarction
• Pulmonary Embolism
• Malignant Neoplasm Of Lung
• Inflammatory Response

• Digeorge Syndrome
• Vascular System Injuries
• Myocardial Infarction
• Tumor Angiogenesis
• Cat Eye Syndrome
• Cerebrovascular Accident
• Osteoporosis

Pathways

• Coagulation
• Osteoclast Differentiation
• Growth Hormone Secretion
• Tube Formation
• Angiogenesis
• Regulation Of Angiogenesis
• Bone Resorption
• Hormone Secretion

• Inflammatory Response
• Secretion

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPIND1

Boster Bio - Best Uses Of The SERPIND1 Marker

To learn more about SERPIND1 and its applications, we've put together this guide. This guide covers Boster Bio's research primary and secondary antibodies, as well as PICOKINE and PICOBAND (tm) ELISA kits. This article is for scientists who are interested in submitting their results to applications, species, and other special samples. These guidelines apply to all scientists worldwide.

Boster Bio offers primary and secondary antibodies for research

Boster Bio is a well-known manufacturer of antibodies. Boster Bio is a leader in antibody research and development. They produce high-quality, validated antibodies as well as ELISA kits for a variety of uses. Boster's high-throughput screening capabilities and result confirmation capabilities allow them provide ELISA/WB services which are optimized for use across a variety of applications. Boster Bio has a wide range of antibodies that can be used in research in many areas, such as medicine and neuroscience. In addition, each product is backed by Boster's quality guarantee, which guarantees that it will perform as claimed.

Immunohistochemistry, a specialized technique for staining cells for antigens and haptens, is used. Boster Bio works closely with its customers to achieve their research goals and stay on the cutting-edge of research. Boster Bio can produce antibodies based on customer specifications. Boster also creates ELISA kits that can detect multiple targets such as cancer, inflammation, or developmental biology. Multiplex Immunohistochemistry services allow for a high-throughput screening and rapid assay processing.

Agrisera is a Swedish antibody company that specializes in monoclonal antibodies for plant proteins. The company also offers pre-made primary antibodies. The company's antibodies are highly specific and are used for protein detection in thousands of plant species. Agrisera was also named the Plant Science Antibody Supplier Award of the Year. Boster Bio is an excellent choice for antibody research, due to this and other reasons. It is also a reliable supplier of research primary and secondary antibodies.

Exbio is an ex-biotechnology company that develops and manufactures high-quality antibodies. Its primary antibodies are suitable for Western Blotting and ELISA as well as High Content Screening. The company also offers a wide selection of diagnostic kits, reagents, and other products for research and development. Exbio is also focused on identifying biomarkers that can be used in multiple therapeutic areas like cardiovascular disease, inflammation and Alzheimer's.

An extensive review of publications citing antibodies revealed the importance of high-quality products. Boster Bio offers more than a thousand antibodies and related reagents. The most commonly cited goat anti-human IgG antibodies is the most well-known, but others have no citations. This list is updated regularly to reflect the latest data. This data aids researchers in choosing the best products that will support their research.

Boster Bio's reagents/kits can help researchers identify and quantify various antigens using different experimental techniques. They are made by immunizing host animals with antibodies of different species. Secondary antibodies recognize the immunoglobulin Ig domains of primary antibodies. They aid in sorting out and purifying primary antibody. In addition, secondary antibodies are usually coupled with a label. The downstream application will dictate the label used.

Boster Bio's PICOKINE (tm) ELISA kits

Boster Bio’s PICOKINETM ELISA kit for the detection SERPIND1 is a great choice for researchers due to its high sensitivity, fast turnaround times and excellent sensitivity. These highly sensitive ELISA kits contain enough reagents for 96 tests, and have been validated for use with a wide range of samples.

Boster Bio's PICOKINETM ELISA kits are fast and sensitive, yet specific. Each kit is optimized to deliver high-quality results. This is critical in research. The ELISA kits come complete with detailed instructions for sample preparation.

Boster Bio has developed the PICOBAND(tm), an ELISA kit.

Boster Bio's PICOBAND ELISAS Kits for the SERPIND1, or serotonin receptor p21 marker are specifically designed for use in cancer research. Developed by Boster Bio, these kits reach picogram levels of sensitivity. Boster Bio antibodies have been tested against over 29,000 publications. They have been tested against untransfected cells and human tissues.

The kit contains 96 wells. Human SERPING1 can also be measured in plasma, human serum, and cell culture supernatants. The ELISA is cross reactive and reactivity-free and is suitable for researchers working with different cellular sources. For more sensitive detection of SERPIND1, this kit uses a blocking peptide to prevent cross-reactivity.