SEM1 Antibodies

AND SEM1 ELISA kits, SEM1 Proteins

Many biological assays use antibodies to detect SEM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SEM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SEM1 antibodies...

We validate the specificity of these antibodies to SEM1 by testing them on tissues known to express SEM1 positively and negatively. Browse below to find the SEM1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SEM1 Infographic by Boster Bio

All SEM1 Products

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Product

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Specificity

Applications

Price

Human SHFM1 Recombinant Protein

SDS-PAGE

$265
Cat # PROTP60896
Starting from 10ug

SEM1 (NM_006304) Human Over-expression Lysate

Human

$628
Cat # LS007979
100 µg

SEM1 Overview

Facts about 26S proteasome complex subunit SEM1.

SEM1 3D structure. Source: alphafold

26S proteasome complex subunit SEM1 (SEM1)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which might impair cellular functions, and by removing proteins whose functions are no longer required.

Hence, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388).

Gene Information

Human
Gene Name:	SEM1
Uniprot:	P60896
Entrez:	7979

Family

Belongs to:

DSS1/SEM1 family

Alternative Names

26S proteasome complex subunit SEM1

Molecular Weight

Mass (kDA):
8.278 kDA

Genomic Context


Human

Location:	7q21.3
Sequence:	7; NC_000007.14 (96481626..96709891, complement)

Tissue Specificity

Expressed in limb bud, craniofacial primordia and skin.

Interacting Proteins

BRCA2
PSMD3

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEM1

References

PMID: 8733122 by Crackower M.A., et al. Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.

PMID: 1317798 by Kanayama H.O., et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.