SCO1 Antibodies

AND SCO1 ELISA kits, SCO1 Proteins

Many biological assays use antibodies to detect SCO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCO1 antibodies...

We validate the specificity of these antibodies to SCO1 by testing them on tissues known to express SCO1 positively and negatively. Browse below to find the SCO1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCO1 Infographic by Boster Bio

All SCO1 Products

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Product

Figures

Specificity

Applications

Price

Anti-SCO1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A02934
0.1 mg

SCO1 (NM_004589) Human Recombinant Protein

$813
Cat # PROTO75880
20 µg

SCO1 (NM_004589) Human Over-expression Lysate

Human

$628
Cat # LS006341
100 µg

Anti-SCO1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A02934-1
100 μg/vial

SCO1 Overview

Facts about Protein SCO1 homolog, mitochondrial.

SCO1 3D structure. Source: alphafold

Protein SCO1 homolog, mitochondrial (SCO1)

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays an essential role in stabilizing MT-CO2/COX2 during its subsequent maturation.

Involved in transporting aluminum to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).

Gene Information

Human
Gene Name:	SCO1
Uniprot:	O75880
Entrez:	6341

Family

Belongs to:

SCO1/2 family

Alternative Names

protein SCO1 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 1 (yeast); SCOD1SCO (cytochrome oxidase deficient, yeast) homolog 1

Molecular Weight

Mass (kDA):
33.814 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (10672474..10697533, complement)

Tissue Specificity

Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.

Subcellular Localizations

Mitochondrion. Mitochondrion inner membrane; Single-pass membrane protein.

Diseases

Spindle Cell Oncocytoma Of The Adenohypophysis
Cytochrome-c Oxidase Deficiency
Mitochondrial Diseases
Cardiomyopathies
Leigh Disease
Copper Deficiency
Muscle Hypotonia
Hypertrophy
Liver Diseases
Liver Failure
Hypertrophic Cardiomyopathy
Malignant Neoplasms

Comatose
Mitochondrial Respiratory Chain Deficiencies
Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Encephalopathies
Hepatitis B
Fetal Growth Retardation

Interacting Proteins

COX17

Pathways

Translation
Transport
Localization
Aerobic Respiration
Photosynthesis
Mitochondrial Translation
Oxidative Phosphorylation
Cell Death
Germination
Excretion
Transposition
Gametophyte Development
Electron Transport

Electron Transport Chain
Aging
Immune Response
Embryo Development
Cellular Respiration
Fermentation
Nitrogen Fixation

PTMs

Phosphorylation
Reduction

Amidation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCO1

References

PMID: 9878253 by Petruzzella V., et al. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.

PMID: 11027508 by Horvath R., et al. Characterization of human SCO1 and COX17 genes in mitochondrial cytochrome-c-oxidase deficiency.