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- Table of Contents
Facts about Synaptotagmin-like protein 1.
Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity). .
Human | |
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Gene Name: | SYTL1 |
Uniprot: | Q8IYJ3 |
Entrez: | 84958 |
Belongs to: |
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No superfamily |
exophilin-7; FLJ14996; JFC1; NADPH oxidase-related, C2 domain-containing protein; SLP1; synaptotagmin-like 1; synaptotagmin-like protein 1
Mass (kDA):
61.857 kDA
Human | |
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Location: | 1p36.11 |
Sequence: | 1; NC_000001.11 (27342022..27353932) |
Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes.
PMID: 11278853 by McAdara Berkowitz J.K., et al. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.
PMID: 18266782 by Holt O., et al. Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.