Synemin Antibodies

AND SYNM ELISA kits, Synemin Proteins

Many biological assays use antibodies to detect Synemin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synemin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synemin antibodies...

We validate the specificity of these antibodies to Synemin by testing them on tissues known to express SYNM positively and negatively. Browse below to find the SYNM antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SYNM Infographic by Boster Bio

All SYNM Products

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Product

Figures

Specificity

Applications

Price

Anti-Desmuslin (SYNM) Mouse Monoclonal Antibody [Clone ID: OTI7H6]

Human

IHC, WB

$523
Cat # M06653
100 µl

Desmuslin (SYNM) (NM_145728) Human Over-expression Lysate

Human

$960
Cat # LS023336
100 µg

Anti-SYNM Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A06653-1
100 µg/vial

SYNM Overview

Facts about Synemin.

SYNM 3D structure. Source: alphafold

Synemin (SYNM)

Type-VI intermediate filament (IF) that has an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and through its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such concerning the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.

Gene Information

Human
Gene Name:	SYNM
Uniprot:	O15061
Entrez:	23336

Family

Belongs to:

intermediate filament family

Alternative Names

desmuslin; DMNEC 1.4.99.1; EC 2.6.1.16; KIAA0353synemin beta; SYNDesmuslin; synemin alpha; synemin; synemin, intermediate filament protein

Molecular Weight

Mass (kDA):
172.768 kDA

Genomic Context


Human

Location:	15q26.3
Sequence:	15; NC_000015.10 (99105069..99136586)

Tissue Specificity

Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell junction, adherens junction. There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.