Nesprin-2 (SYNE2)

Multi-isomeric modular protein that creates a linking network between organelles and the actin cytoskeleton to keep the subcellular spatial organization. As a Part of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton.

The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines that are bound to F-actin cables and couple the nucleus to retrograde actin flow through actin-dependent nuclear movement.