Nesprin-1 (SYNE1)

Multi-isomeric modular protein which creates a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the link between the nuclear lamina and the cytoskeleton.

The nucleocytoplasmic interactions created by the LINC complex play an essential role in the transmission of mechanical forces across the nuclear envelope and in atomic movement and positioning. May be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and likely association with cytoplasmic dynein-dynactin motor complexes; SYNE1 and SYNE2 may act redundantly.