SMCHD1 Antibodies

AND SMCHD1 ELISA kits, SMCHD1 Proteins

Many biological assays use antibodies to detect SMCHD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMCHD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMCHD1 antibodies...

We validate the specificity of these antibodies to SMCHD1 by testing them on tissues known to express SMCHD1 positively and negatively. Browse below to find the SMCHD1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMCHD1 Infographic by Boster Bio

All SMCHD1 Products

Product

Figures

Specificity

Applications

Price

Anti-SMCHD1 Antibody

Human, Mouse, Rat

IF, WB

$405
Cat # A04751
100ul

Anti-SMCHD1 Rabbit Monoclonal Antibody

Human

IHC, WB

$370
Cat # M04751
100 μl/vial

Anti-SMCHD1 Antibody Picoband™

Human

ELISA, IF, ICC, WB

$370
Cat # A04751-1
100 μg/vial

SMCHD1 Overview

Facts about Structural maintenance of chromosomes flexible hinge domain-containing protein 1.

SMCHD1 3D structure. Source: alphafold

Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)

Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands gradually and requires the methyltransferase DNMT3B (By similarity).

Required for DUX4 silencing in somatic cells (PubMed:23143600). .

Gene Information

Human
Gene Name:	SMCHD1
Uniprot:	A6NHR9
Entrez:	23347

Family

Belongs to:

SMC family

Alternative Names

DKFZp686O0631; KIAA0650; structural maintenance of chromosomes flexible hinge domain containing 1; structural maintenance of chromosomes flexible hinge domain-containing protein 1

Molecular Weight

Mass (kDA):
226.374 kDA

Genomic Context


Human

Location:	18p11.32
Sequence:	18; NC_000018.10 (2655726..2805017)

Subcellular Localizations

Chromosome. Recruited to inactivated chromosome X in females by Xist RNA (By similarity). Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:25294876, PubMed:24790221).

Diseases

Williams Syndrome
Muscular Dystrophy, Facioscapulohumeral
Dystrophy
Muscular Dystrophy

Pathways

Gene Silencing
Methylation
Dna Methylation
Rna-directed Dna Methylation
Chromatin Modification
Localization

Dosage Compensation

PTMs

Methylation

Sumoylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMCHD1

References

PMID: 23542155 by Nozawa R.S., et al. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.

PMID: 25294876 by Tang M., et al. Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage.