Synapsin-2 Antibodies

Synapsin-2 (SYN2)

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is thought to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).

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Gene Information

Human
Gene Name:	SYN2
Uniprot:	Q92777
Entrez:	6854

Family

Belongs to:
synapsin family

Alternative Names

synapsin IISYNII; synapsin-2; SYNIIa; SYNIIb

Molecular Weight

Mass (kDA):
62.996 kDA

Genomic Context

Human
Location:	3p25.2
Sequence:	3; NC_000003.12 (12004360..12192032)

Tissue Specificity

Central and peripheral nervous systems.

Subcellular Localizations

Cell junction, synapse.

Diseases

• Schizophrenia
• Epilepsy
• Bipolar Disorder
• Impaired Cognition
• Autoimmunity
• Ataxia
• Neuromuscular Diseases
• Aneuploidy
• Manic
• Opisthotonus
• Insulin Resistance
• Memory Disorders

• Paroxysmal Nocturnal Dyspnea
• Neoplasms
• Nervousness
• Memory Impairment
• Dysequilibrium Syndrome
• Epilepsy, Temporal Lobe
• Stress, Psychological

Pathways

• Localization
• Mitosis
• Meiosis
• Aging
• Megagametogenesis
• Chromosome Segregation
• Sister Chromatid Cohesion
• Pathogenesis
• Dna Recombination
• Cell Division
• Drug Resistance

• System Development
• Female Meiosis
• Locomotion
• Interphase
• Eye Development
• Rrna Processing

PTMs

• Glycosylation

Research Areas

• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYN2

Boster Bio: Best Uses Of The Selectable SYN2 Marker

Boster Bio: Best Uses of The Selectable Syn2 Marker is for all scientists. This versatile marker allows scientists the ability to submit results for species and applications as well as special samples. Earn product credits for sharing your results. The best part? The Boster Bio: Selectable SYN2 Marker is suitable for all scientists around the world.

Selectable Marker

A new SNP that can accurately identify synuclein defects, the selectable SYN2 marker, has been identified. The SYN2 genes encodes a protein with two distinct isoforms. The SYN2 isoform has been associated with repetitive and social behavior. The SYN2 mutation causes the most severe phenotype. This mutation also causes altered exploration in a new environment and increased self care.

Using the selective SYN2 marker, scientists can identify the genes that control the activity of synuclein and other proteins. E. coli considers genes that encode antibiotic resistance selectable markers if they are expressed in bacteria. The exact mechanism of SYN2 expression is still unknown. The current study shows that a specific SYN2 marker can detect SV resistance to hSyn I in a single cell.

Researchers have found that autism and ASD are linked to several SYN2 mutations. These mutations affect SYN2's ability targeting nerve terminals and causing synapses. SYN2 mutations can also cause autism or epilepsy in affected individuals. Despite the lackluster consensus, the SYN2 mutation is a candidate marker to diagnose ASD and epilepsy.

The SYN2S10A mutant partially rescues syn2KO mice's phenotype. Its functions include tethering synaptic and directing them toward Ca2+ channels. In synaptic activity, the SYN2S10A mutant reduces spontaneous synaptic activity, but not epileptic activity. Its lack causes synaptic plasticity loss, which can lead to an imbalance in excitatory and inhibitive neurons.

Neuronal cultures have been extensive in their study. Their molecular interactions in synapses are still not fully understood, and their synaptic functions remain a mystery. However, major functions of Syn II involve bindisomes in a phosphorylation-dependent manner, clustering of synaptic vesicles, and directing them to release.

Similarly, Syn II phosphorylation at site P1 contributes to the ability of the brain to balance epilepsy predisposition. These genes are also linked to the pathogenesis many neurodevelopmental disorders, such as autism. Selectable SYN2 markers have been sought. It is crucial to understand how synaptic proteins work in the brain. A genetic test of Syn 2 is the best method to determine if these genes are pathogenic.

Some examples of applications

SYN2 can be described as a dsDNA-derived gene with an S sequence derived form MIA. This study used the dsDNA sequencing to identify target DNA. It was used with concentrations up to 0.01 uM. Figure 4 clearly shows that the frequency shift was visible between the higher-frequency probe (control) and the lower-frequency probe (probe). This demonstrates the sensitivity of the biosensor to detect short dsDNA strands. In order to determine the maximum frequency shift, we experimented with different concentrations dsDNA and varied query fields. The frequency shift of 20 uM to 0.01 uM was strongly correlated with surface occupation.

The CA1 area of the hippocampus hosts the Syn II marker. We used mice with Syn2KO for these experiments. The brains of mice were used for immunohistochemistry simultaneously. The Syn II marker was detected in both mouse and WT samples, and the antibody also recognizes the shorter isoform. Syn II expression is usually elevated in the hippocampus in schizophrenic patients.

This marker has many possible applications. One example is its association to epilepsy. The 3p25.2 location of the SYN2 gene in humans and other animals is where it can be found. Besides humans, it has homologs in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. 215 of these organisms have the SYN2 genetic code.