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SYCP1 Antibodies
AND SYCP1 ELISA kits, SYCP1 Proteins
Many biological assays use antibodies to detect SYCP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SYCP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SYCP1 antibodies...
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SYCP1 Overview
Facts about Synaptonemal complex protein 1.
Synaptonemal complex protein 1 (SYCP1)
Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes.
Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal female and male fertility.
Gene Information
| Human | |
|---|---|
| Gene Name: | SYCP1 |
| Uniprot: | Q15431 |
| Entrez: | 6847 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cancer/testis antigen 8; CT8MGC104417; HOM-TES-14; SCP1SCP-1; synaptonemal complex protein 1
Molecular Weight
Mass (kDA):
114.192 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.2 |
| Sequence: | 1; NC_000001.11 (114854268..114995370) |
Tissue Specificity
Testis.
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity).
Diseases
- Neoplasms
- Infertility
- Aneuploidy
- Malignant Neoplasms
- Male Infertility
- Testicular Neoplasms
- Azoospermia
- Lymphoma
- Malignant Paraganglionic Neoplasm
- Seminoma
- Myeloid Leukemia
- Oligospermia
Pathways
- Meiosis
- Prophase
- Pachytene
- Spermatogenesis
- Localization
- Male Meiosis
- Metaphase
- Zygotene
- Meiotic Prophase I
- Chromosome Segregation
- Meiosis I
- Diplotene
- Female Meiosis
PTMs
- Methylation
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- Chromatin Research
- Growth and Development
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYCP1
bosterbio.com/bosterbio-gene-info-cards/SYCP1
References
PMID: 9119375 by Meuwissen R.L.J., et al. Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene.
PMID: 9371398 by Kondoh N., et al. Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis.