FACT complex subunit SPT16 (SUPT16H)

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in numerous processes that need DNA as a template such as mRNA elongation, DNA replication and DNA repair.

During transcription elongation that the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It eases the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.