This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about FACT complex subunit SPT16.
During transcription elongation that the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It eases the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Human | |
---|---|
Gene Name: | SUPT16H |
Uniprot: | Q9Y5B9 |
Entrez: | 11198 |
Belongs to: |
---|
peptidase M24 family |
CDC68; Chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT complex subunit SPT16; FACT140; FACTp140; FACTP140FACT; FLJ10857; FLJ14010; FLJ34357; hSPT16; SPT16/CDC68; suppressor of Ty (S.cerevisiae) 16 homolog; suppressor of Ty 16 homolog (S. cerevisiae)
Mass (kDA):
119.914 kDA
Human | |
---|---|
Location: | 14q11.2 |
Sequence: | 14; NC_000014.9 (21351472..21384019, complement) |
Ubiquitous.
Nucleus. Chromosome. Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
PMID: 10421373 by Orphanides G., et al. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.
PMID: 10792464 by Kang S.-W., et al. Functional interaction of general transcription initiation factor TFIIE with general chromatin factor SPT16/CDC68.