SUN domain-containing protein 1 (SUN1)

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions created by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and placement (By similarity).

Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope at the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex by which SUN1 and SUN2 seem to act at least partial redundantly (By similarity).