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SUMO3 Antibodies
AND SUMO3 ELISA kits, SUMO3 Proteins
Many biological assays use antibodies to detect SUMO3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SUMO3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SUMO3 antibodies...
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SUMO3 Overview
Facts about Small ubiquitin-related modifier 3.
Small ubiquitin-related modifier 3 (SUMO3)
Ubiquitin-like protein which may be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not appear to be involved in protein degradation and might function as an antagonist of ubiquitin in the degradation process.
Plays a role in several of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and may be promoted by means of an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678).
Gene Information
| Human | |
|---|---|
| Gene Name: | SUMO3 |
| Uniprot: | P55854 |
| Entrez: | 6612 |
Family
| Belongs to: |
|---|
| ubiquitin family |
Alternative Names
SMT3 (suppressor of mif two 3, yeast) homolog 1; SMT3 homolog 1; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 3 (yeast); SMT3A; SMT3B; SMT3H1; SMT3H1small ubiquitin-related modifier 3; SUMO-2; SUMO3; SUMO-3; ubiquitin-like protein SMT3A; Ubiquitin-like protein SMT3B
Molecular Weight
Mass (kDA):
11.637 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (44805617..44818129, complement) |
Tissue Specificity
Expressed predominantly in liver.
Subcellular Localizations
Cytoplasm. Nucleus. Nucleus, PML body.
Diseases
- Neoplasms
- Leukemia
- Acute Promyelocytic Leukemia
- Malignant Neoplasms
- Ischemia
- Cerebral Ischemia
- Down Syndrome
- Transient Ischemic Attack
- Physiological Stress
- Trisomy
- Transient Cerebral Ischemia
- Hypoxia
Interacting Proteins
- SART1
- SENP2
- SP100
- USPL1
Pathways
- Conjugation
- Localization
- Cell Cycle
- Protein Sumoylation
- Dna Replication
- Transport
- Mitosis
- Translation
- S Phase
- Chromosome Segregation
- Cytokinesis
- Nuclear Transport
- Interphase
PTMs
- Sumoylation
- Phosphorylation
- Ubiquitination
- Cleavage
- Acetylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SUMO3
bosterbio.com/bosterbio-gene-info-cards/SUMO3
References
PMID: 9119407 by Lapenta V., et al. SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
PMID: 10692421 by Saitoh H., et al. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.