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Sulfotransferase 2B1 Antibodies
AND SULT2B1 ELISA kits, Sulfotransferase 2B1 Proteins
Many biological assays use antibodies to detect Sulfotransferase 2B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sulfotransferase 2B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sulfotransferase 2B1 antibodies...
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SULT2B1 Infographic by Boster Bio
All SULT2B1 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9822
100 μg/vial
Cat # PB9822
100 μg/vial
SULT2B1 Overview
Facts about Sulfotransferase 2B1.
Sulfotransferase 2B1 (SULT2B1)
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also lead to bioactivation to form active metabolites.
Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
Gene Information
| Human | |
|---|---|
| Gene Name: | SULT2B1 |
| Uniprot: | O00204 |
| Entrez: | 6820 |
Family
| Belongs to: |
|---|
| sulfotransferase 1 family |
Alternative Names
Alcohol sulfotransferase; Cytosolic Sulfotransferase 2B1; EC 2.8.2; EC 2.8.2.2; HSST2; HSST2sulfotransferase family cytosolic 2B member 1; Hydroxysteroid sulfotransferase 2; ST2B1; Sulfotransferase 2B1; sulfotransferase family, cytosolic, 2B, member 1; SULT2B1
Molecular Weight
Mass (kDA):
41.308 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (48552172..48599427) |
Tissue Specificity
Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
Subcellular Localizations
Cytoplasm, cytosol. Microsome. Nucleus. Phosphorylation of Ser-348 is required for translocation to the nucleus.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasms, Hormone-dependent
- Steroid Sulfatase Deficiency Disease
- Choriocarcinoma
- Hyperplasia
- Endometrial Polyp
- Carcinoma
- Neoplasms
- Malignant Neoplasm Of Prostate
- Adenocarcinoma
- Secondary Malignant Neoplasm
Interacting Proteins
- ACYP2
- ALS2CR12
- PRICKLE3
- SULT1A1
- SULT1B1
Pathways
- Sulfation
- Localization
- Conjugation
- Reverse Transcription
- Transport
- Cell Proliferation
- Fermentation
- Secretion
- Cell Activation
- Regulation Of Cholesterol Homeostasis
- T Cell Activation
- Aging
- Immune Response
PTMs
- Sulphation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SULT2B1
bosterbio.com/bosterbio-gene-info-cards/SULT2B1
References
PMID: 9799594 by Her C., et al. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene.
PMID: 12145317 by Fuda H., et al. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.