Extracellular sulfatase Sulf-1 (SULF1)

Exhibits arylsulfatase activity and extremely specific endoglucosamine-6-sulfatase activity. It can remove sulfate in the C-6 place of glucosamine within specific subregions of intact heparin.

Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. .