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- Table of Contents
Facts about Extracellular sulfatase Sulf-1.
Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation. .
Human | |
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Gene Name: | SULF1 |
Uniprot: | Q8IWU6 |
Entrez: | 23213 |
Belongs to: |
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sulfatase family |
EC 3.1.6; EC 3.1.6.-; EC 3.1.6.14; extracellular sulfatase Sulf-1; FLJ30905; FLJ38022; FLJ41750; hSulf-1; KIAA1077sulfatase FP; SULF-1; sulfatase 1
Mass (kDA):
101.027 kDA
Human | |
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Location: | 8q13.2-q13.3 |
Sequence: | 8; NC_000008.11 (69466624..69660912) |
Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Also localized on the cell surface.
PMID: 12368295 by Morimoto-Tomita M., et al. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.
PMID: 12686563 by Lai J., et al. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.